Genetic study redefines a form of excessive sweating as a treatable neurological condition

A Tiny Electrical Gate in Nerve Cells May Be Behind Excessive Sweating

Learn how an inherited genetic change may cause excessive sweating by making the nerves that control sweat glands respond too strongly.

Genetic study redefines a form of excessive sweating as a treatable neurological condition

An international research team led by Dr. Frank Bosmans (Vrije Universiteit Brussel) has discovered a major genetic cause of hyperhidrosis (chronic and excessive sweating). The study, published in Science Advances, provides strong evidence that a genetically determined form of hyperhidrosis arises from overstimulation of the nerves that control the sweat glands. The discovery removes the stigma surrounding the condition and paves the way for targeted treatments using existing medicines.

The genetic switch that causes excessive sweating revealed, new hopes for hyperhidrosis - JIJI PRESSThe genetic switch that causes excessive sweating revealed, new hopes for hyperhidrosis

NEWS JIJI PRESS

Genetic Cause of Chronic Excessive Sweating Discovered

A new study establishes that primary hyperhidrosis is driven by a genetic defect in the Nav1.8 voltage-gated sodium channel.

Genetic Study Links Excessive Sweating to Neurological Dysfunction

Data from a new study suggest that a form of hyperhidrosis, or excessive sweating, may be due to genetic mutations that result in the overstimulation of the nerves that control the sweat glands. These findings, which are reported in Science Advances, could open a door to targeted treatments for the condition using existing medicines. Full details of the findings are provided in the paper titled “A neurocutaneous NaV1.8 channelopathy underlies a …