Functional Targeting of ILC2s and ILC3s Reveals Selective Roles in Intestinal Fibrosis and Homeostasis - Science in Vancouver

Functional Targeting of ILC2s and ILC3s Reveals Selective Roles in Intestinal Fibrosis and Homeostasis - Science in Vancouver

Innate lymphoid cells (ILCs) are long-lived, tissue-resident cell analogs to T helper subsets that lack antigen-specific receptors. Understanding the roles of specific ILCs in chronic inflammation and fibrosis has been limited by inadequate tools for selective targeting. Here, we used Il17rb-CreERT2-eGFP and Rorc-Cre strains to selectively delete RORα in ILC2s and ILC3/Th17 cells, respectively. RORα deletion in ILC2s caused significant loss of g…