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49ers All-Pro Linebacker Fred Warner Carted Off Following Gruesome Ankle Injury

Fred Warner suffered a severe right ankle injury early in the game and was ruled out, further depleting the 49ers' defense already missing Nick Bosa, officials said.

  • On Sunday, Oct. 12, 2025, San Francisco 49ers middle linebacker Fred Warner was carted off during the first half in Tampa, leaving with a leg cast and ruled out in the locker room.
  • On a 10-yard run with 7:48 left in the first quarter, Fred Warner's right ankle twisted after players fell into him and Ji'Ayir Brown rolled into the back of his ankle.
  • The CBS broadcast briefly showed the replay once due to its gruesome nature, while almost the entire San Francisco 49ers bench cleared and multiple players knelt as medical staff tended to Warner.
  • The 49ers, already shorthanded, lost another defensive leader as second-year linebacker Tatum Bethune entered to replace Warner during Week 6 at 4-1, deepening injury challenges.
  • Warner's absence removes an elite, durable leader from the defense; he was five tackles shy of Patrick Willis' franchise record before the injury.
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NBC Bay Area broke the news in San Francisco, United States on Sunday, October 12, 2025.
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