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First US Death from Tick-Bite Meat Allergy Documented

The 47-year-old man’s fatal allergic reaction followed a tick bite causing alpha-gal syndrome, a condition now affecting up to 450,000 Americans, researchers said.

  • In September 2024, researchers at the University of Virginia School of Medicine reported that a 47-year-old New Jersey man died after falling ill four hours following a hamburger at a barbecue, marking the first known U.S. death from tick-bite meat allergy.
  • Mechanistically, when ticks feed on mammals they transfer alpha-gal, a sugar in mammal blood that can trigger delayed red-meat allergy, most cases linked to the lone star tick, researchers say.
  • Medical evidence tied to the case includes blood testing showing alpha-gal antibodies linked to fatal anaphylaxis, the autopsy ruled sudden and unexplained, and the man's son found him unconscious surrounded by vomit.
  • Researchers say this case highlights a mounting threat as lone star ticks and white-tailed deer migrate; the CDC reported more than 110,000 suspected cases, with 42% of health care providers unaware and no vaccine available.
  • Experts note that exercise and alcohol increase allergy absorption, and Thangamani advised that `We can't reduce the tick exposure, but if we can remove the tick as soon as we come from an outdoor activity, we essentially eliminate a lot of issues that arise after a tick bite.
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Queensland Country Life broke the news in on Thursday, November 13, 2025.
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