Fat-rich fluid found to fuel immune failure in ovarian cancer

Fat-rich fluid found to fuel immune failure in ovarian cancer

New research led by Irish scientists has uncovered how lipid-rich fluid in the abdomen, known as ascites, plays a central role in weakening the body's immune response in advanced ovarian cancer. The findings offer new insights into immune suppression in ovarian cancer and open promising avenues for future immunotherapy approaches.

The skinny on fat, ascites and anti-tumor immunity

A Ludwig Cancer Research study has identified a key mechanism by which advanced ovarian cancers suppress anti-tumor immune responses and resist immunotherapies.

Unraveling the Link Between Fat, Ascites, and Anti-Tumor Immunity

Emerging research from Ludwig Cancer Research’s Princeton branch unveils a pivotal mechanism by which advanced ovarian cancers subvert immune defenses, shedding light on a long-standing enigma in tumor immunology. Published in the latest issue of Science Immunology, this groundbreaking study delves into the immunosuppressive role of ascites fluid—a lipid-rich milieu pervasive in the peritoneal cavities of patients with metastatic high-grade sero…

Immune Response in Advanced Ovarian Cancer Weakened by Phospholipids in Ascites

Research, headed by teams at Trinity College Dublin and University College Dublin, has uncovered how lipid-rich fluid in the abdomen, known as ascites, plays a central role in weakening the body’s immune response in advanced ovarian cancer. The scientists explored how ascites disrupt immune cell function, with a particular focus on natural killer (NK) cells and T cells, which are key players in the body’s ability to eliminate tumors. By analyzin…