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‘Brilliant Minds’: Eric Dane to Guest Star — See Him on Set With Zachary Quinto

Eric Dane's role as a firefighter with ALS mirrors his own diagnosis, adding emotional depth to Brilliant Minds Season 2, which explores neurological conditions, producers said.

  • On October 20, NBC announced Eric Dane will guest star as Matthew, a heroic firefighter confronting ALS, in Brilliant Minds Season 2’s ninth episode, episode 209.
  • On April 10, Dane announced his ALS diagnosis to People, describing early right-hand symptoms and a nearly year-long path to diagnosis as the disease caused muscle control loss.
  • The network released on-set photos showing Eric Dane alongside star Zachary Quinto in Brilliant Minds, an NBC drama inspired by Oliver Sacks and following Dr. Oliver Wolf.
  • Amid his health challenges, Dane recently missed the Grey’s Anatomy reunion at the 77th Emmy Awards but remains active with Euphoria Season 3 and Countdown.
  • Brilliant Minds airs on NBC Mondays at 10 p.m. ET with new episodes streaming the next day on Peacock; the ensemble includes Tamberla Perry, Ashleigh LaThrop, Alex MacNicoll, Aury Krebs, Spence Moore II, Teddy Sears, Donna Murphy, and Michael Grassi serves as writer and executive producer.
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‘Brilliant Minds’: Eric Dane to Guest Star — See Him on Set With Zachary Quinto

See Dane on set with Zachary Quinto and find out who he'll be playing.

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Deadline broke the news in Los Angeles, United States on Monday, October 20, 2025.
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