Elimination of “lag” and “burst” phases in drug release profiles of melt-extruded, PLGA-based intravitreal implants - Pharma Excipients
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Elimination of “lag” and “burst” phases in drug release profiles of melt-extruded, PLGA-based intravitreal implants - Pharma Excipients
Abstract Drug delivery products based on poly(lactic-co-glycolic acid) (PLGA) often have multiphasic drug release profiles with slow “lag phase(s)” and rapid “burst phase(s),” which can limit therapeutic efficacy. The purpose of this study was to develop voriconazole (VCZ)/PLGA intravitreal implants with steady drug release profiles, i.e., without lag and burst phases. This study was performed by manufacturing several implant formulations by mel…
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