US EditionNovel mRNA Nanoparticle Exposes Hidden HIV in White Blood Cells
- Researchers at Melbourne's Peter Doherty Institute discovered a method to expose HIV hidden in white blood cells as reported in May 2025.
- This breakthrough addresses the main challenge that HIV hides inside resting CD4+ T cells, making it undetectable by the immune system and treatments.
- The team developed a novel lipid nanoparticle called LNP X that successfully delivers mRNA into these cells, a feat previously thought impossible.
- One dose of Tat-LNP X increased HIV RNA by 112-fold, with researchers describing this as a 'night and day difference' and reacting with gasps of 'wow.'
- Though the virus was exposed and not eliminated, this advance could lead to combining reactivation with cell-killing therapies, marking progress toward an HIV cure.
46 Articles
46 Articles
Australian scientists claim to have found a new way to attack the HIV reservoir to force it "out of its hiding place."
Doctors Near HIV Cure with ‘Previously Impossible’ Discovery: ‘We Have Never Seen Anything Close to As Good’ - News Addicts
An estimated 39 million people around the world are living with HIV — and, while treatment options can ensure they have long, healthy lives, there is no known cure. Antiretroviral therapy (ART) — the most effective current treatment — can reduce HIV levels in the body so low the virus is almost undetectable. However, the […] The post Doctors Near HIV Cure with ‘Previously Impossible’ Discovery: ‘We Have Never Seen Anything Close to As Good’ appe…
"Gasping": Scientists Make Breakthrough Toward Full Cure for HIV
Researchers say they've taken a major step toward finding a cure for HIV. As The Guardian reports, scientists at the Peter Doherty Institute for Infection and Immunity in Melbourne found a way to make the HIV virus visible, potentially laying the groundwork for ways to banish it from the body altogether. As detailed in a paper published in the journal Nature Communications, the team developed a way to send messenger RNA into cells, to root out t…
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