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Effects of antidepressants on physical health ranked for first time

A review of 30 antidepressants involving over 58,000 patients found weight changes up to 4 kg and heart rate differences over 20 beats per minute, emphasizing personalized treatment.

  • A study ranked the side effects of 30 antidepressants based on their impact during the first eight weeks of treatment, revealing that patients may gain or lose weight depending on the medication prescribed.
  • The research, led by experts from King’s College London’s IoPPN, analyzed data from 58,534 participants and was published in The Lancet.
  • Certain antidepressants can lead to a weight change of about 4kg, with some medications linked to significant heart rate and blood pressure alterations.
  • Experts emphasize the need for shared decision-making in treatment and for regular health check-ups for patients starting antidepressants.
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Medical Xpress broke the news in on Tuesday, October 21, 2025.
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