Effect of Focused Ultrasound Neuromodulation of the Superior Mesenteric Plexus on Insulin Sensitivity and Post-Operative Hyperglycemia in a Swine Model of Surgical Stress
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Effect of Focused Ultrasound Neuromodulation of the Superior Mesenteric Plexus on Insulin Sensitivity and Post-Operative Hyperglycemia in a Swine Model of Surgical Stress
Abstract Metabolic stress during major surgery increases insulin resistance and causes post-operative hyperglycemia (POHG), which may in turn contribute to post-operative morbidity and mortality. Intensive insulin therapy for POHG is often ineffective and may even worsen patient outcomes. Non-invasive focused ultrasound stimulation (FUS) of glucose-sensing abdominal neurons improves glucose metabolism in animal models of diabetes, but its potent…
·Charlottesville, United States
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