Do typhoid conjugate vaccines prevent acute typhoid fever and are they safe?

Do typhoid conjugate vaccines prevent acute typhoid fever and are they safe?

Do typhoid conjugate vaccines prevent acute typhoid fever and are they safe? Key messages Compared to a control (no vaccine, placebo ('dummy') or vaccine for another disease), typhoid conjugate vaccines (TCVs) may result in a large decrease in acute typhoid fever cases. We are uncertain whether TCVs, compared to other typhoid vaccines, decrease acute typhoid cases. There may be little to no difference in death from any cause, and unwanted effect…