US EditionWnt/β-catenin/HNF4α feedback loop facilitates colorectal tumorigenesis and malignancy
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A group of researchers from the National Center for Oncological Research (CNIO) has discovered a molecular mechanism involved in the formation of colorectal tumors, which favors their progression towards more aggressive forms, opening up new avenues for the development of strategies for the prevention of this type of cancer.
Read a quick summary generated by AI × Summary of the news: A recent study by the National Center for Oncological Research (CNIO) has identified a key molecular mechanism in the development of colon cancer. According to researchers, the p53 protein shortage triggers the formation of colorectal tumors in animal models, which could have significant implications for the understanding and treatment of this type of cancer. This discovery highlights t…
Wnt/β-catenin/HNF4α feedback loop facilitates colorectal tumorigenesis and malignancy
Background: The Wnt/β-catenin signaling pathway is a central regulator of colorectal cancer (CRC) development, yet its downstream targets and mechanistic contributions to tumorigenesis remain poorly defined. Hepatocyte nuclear factor 4 alpha (HNF4α), a transcription factor pri...
Colorectal cancer – from the colon or rectum – is the third most diagnosed type of cancer worldwide. Up to 80% of cases are related to environmental and lifestyle factors, such as unhealthy diet, sedentary lifestyle, obesity, smoking, or excessive alcohol consumption. Most colorectal cancers originate from adenomatous polyps, a precancerous lesion that, if not detected and removed in time, can evolve into a malignant tumor. A recent study publis…
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