Genome-Wide SNP and CNV Analysis Identifies Common and Low-Frequency Variants Associated with Severe Early-Onset Obesity

Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity

Sadaf Farooqi, Inês Barroso and colleagues report genome-wide SNP and CNV association analyses for severe obesity in children, selected at the extreme of the distribution for body mass index. They identify four loci newly associated with severe obesity, an enrichment of rare CNVs in severely obese cases and overlap in the loci associated with severe obesity in children and with BMI and obesity in the general population. Common and rare variants …

🧬 DeepMind's new AI identifies the gene variants most likely to cause disease

AlphaGenome can predict how individual DNA changes affect gene expression and protein production across the entire human genome.The tool outperformed 22 of 24 other computer models in identifying specific features in DNA sequences.Academic researchers can use AlphaGenome free of charge while DeepMind works on commercial availability.AI model analyzes entire genomeDeepMind has developed AlphaGenome, an AI tool that can explain how genetic changes…