US EditionStudy links diabetes drug to reduced arthritis pain in knees
- In an April 2025 clinical trial, researchers at Monash University found that metformin alleviated knee osteoarthritis pain in overweight or obese individuals over a treatment duration of six months.
- The trial compared metformin to placebo in 107 participants with symptomatic knee osteoarthritis, aiming to find a new treatment option beyond exercise and weight loss, which many find difficult.
- The metformin group experienced a 31.3 point reduction in pain, notably greater than the 18.9 point reduction in the placebo group, and the drug works by affecting inflammation and metabolic pathways in the knee.
- Lead researcher Professor Flavia Cicuttini highlighted that metformin, a safe and low-cost medication familiar to many GPs, offers a promising new option to reduce knee pain associated with arthritis and may help postpone the need for knee replacement surgery.
- While these results suggest metformin could improve knee osteoarthritis management and reduce surgery need, Cicuttini noted confirmation in larger trials is necessary due to the modest sample size.
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Common diabetes drug could spark knee-pain breakthrough, study finds
A new study has uncovered another benefit of one of the country's most commonly prescribed medications for diabetes - joint pain relief.More than six million scripts for metformin are written each year, mainly to treat type 2 diabetes.Researchers at Monash University led a study to see whether the safe and inexpensive tablets could be repurposed to manage pain for those with knee arthritis.READ MORE: Man arrested after teenager fatally shot at N…
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Repurposed diabetes drug can reduce pain for those with knee arthritis and overweight or obesity, clinical trial shows
A common diabetes drug can reduce the pain of people with knee osteoarthritis and overweight or obesity, possibly delaying the need for knee replacements, Monash University-led research has found.
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