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Cocrystal of metaxalone and succinic acid: Research on spectroscopic characterization, Molecular Vibration Mode and Dissolution Performance Optimization
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1 Articles
1 Articles
Cocrystal of metaxalone and succinic acid: Research on spectroscopic characterization, Molecular Vibration Mode and Dissolution Performance Optimization
Abstract Metaxalone is a muscle relaxant. However, its low solubility limits its bioavailability. Drug cocrystal technology can improve the physicochemical properties of the active pharmaceutical ingredient, achieving a synergistic effect without altering the mechanism of action of the drug. In this paper, a drug cocrystal composed of metaxalone and succinic acid in a stochemical ratio of 2:1 was prepared. Its formation was confirmed by characte…
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