US EditionAlzheimer’s Breakthrough: Scientists Identify Key Enzyme That Links Brain Inflammation to Memory Loss
- Scientists identified that the enzyme-related inflammation in the brain links peripheral stress to memory loss and neurodegeneration in aging mice after surgery.
- This finding followed research showing that senescent cells accumulate with age and produce inflammatory signals that worsen brain inflammation after peripheral stress.
- The study used orthopedic surgery in aged mice and demonstrated that senolytic drugs dasatinib and quercetin reduced senescent cell burden and neuroinflammation significantly.
- Treatment lowered circulating proinflammatory factors and glial cell activity, supporting the idea that clearing senescent cells can mitigate surgery-induced brain inflammation.
- These results imply senolytic therapies have potential to prevent cognitive decline from peripheral stress and support public health efforts promoting midlife physical activity to reduce Alzheimer's risk.
14 Articles
14 Articles
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Alzheimer’s Breakthrough: Scientists Identify Key Enzyme That Links Brain Inflammation to Memory Loss
SIRT2, an enzyme previously overlooked in astrocytic GABA production, may be crucial for distinguishing the specific effects of degenerative molecules involved in Alzheimer’s disease. A research team at the Institute for Basic Science (IBS) has discovered that SIRT2, an enzyme previously unknown in this context, plays a key role in memory loss linked to Alzheimer’s [...]
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Breakthrough progress on the role of proteins in Alzheimer’s
Sharing their motivation and personal experiences behind Race Against Dementia, Sir Jackie and Mark Stewart spoke to ITV News and The Guardian this week to celebrate the progress in brain tissue examination by Dr Claire Durrant. Read the ITV News article and watch the interview Read The Guardian article Someone develops dementia every three seconds, […]
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