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Alzheimer’s Breakthrough: Scientists Identify Key Enzyme That Links Brain Inflammation to Memory Loss

  • Scientists identified that the enzyme-related inflammation in the brain links peripheral stress to memory loss and neurodegeneration in aging mice after surgery.
  • This finding followed research showing that senescent cells accumulate with age and produce inflammatory signals that worsen brain inflammation after peripheral stress.
  • The study used orthopedic surgery in aged mice and demonstrated that senolytic drugs dasatinib and quercetin reduced senescent cell burden and neuroinflammation significantly.
  • Treatment lowered circulating proinflammatory factors and glial cell activity, supporting the idea that clearing senescent cells can mitigate surgery-induced brain inflammation.
  • These results imply senolytic therapies have potential to prevent cognitive decline from peripheral stress and support public health efforts promoting midlife physical activity to reduce Alzheimer's risk.
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fightaging.org broke the news in on Tuesday, April 29, 2025.
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