Alzheimer’s Breakthrough: Scientists Identify Key Enzyme That Links Brain Inflammation to Memory Loss
- Scientists identified that the enzyme-related inflammation in the brain links peripheral stress to memory loss and neurodegeneration in aging mice after surgery.
- This finding followed research showing that senescent cells accumulate with age and produce inflammatory signals that worsen brain inflammation after peripheral stress.
- The study used orthopedic surgery in aged mice and demonstrated that senolytic drugs dasatinib and quercetin reduced senescent cell burden and neuroinflammation significantly.
- Treatment lowered circulating proinflammatory factors and glial cell activity, supporting the idea that clearing senescent cells can mitigate surgery-induced brain inflammation.
- These results imply senolytic therapies have potential to prevent cognitive decline from peripheral stress and support public health efforts promoting midlife physical activity to reduce Alzheimer's risk.
14 Articles
14 Articles
Alzheimer’s Breakthrough: Scientists Identify Key Enzyme That Links Brain Inflammation to Memory Loss
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