US EditionClassics in Drug Discovery: A History of the Statins
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Classics in Drug Discovery: A History of the Statins
13 years after the loss of patent exclusivity, atorvastatin (Lipitor®) remains the highest grossing small molecule in pharmaceutical history, redefining what a “blockbuster” drug can be. However, this commercial success was just the dramatic exclamation point to the statin story that encompassed Nobel prizes, blockbuster drugs, and 30+ years of target biology inquiry and drug discovery. This review will highlight the history of, and challenges a…
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