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Chronic stress may trigger hidden inflammation that damages the heart

Researchers found higher inflammation was linked to silent heart remodeling and a 43% greater risk of heart attack and stroke.

  • On Friday, a study published in the European Journal of Preventive Cardiology revealed that chronic inflammation is linked to hidden structural heart damage, analyzing health data from 488,079 adults in the United Kingdom Biobank.
  • Higher inflammation levels were strongly associated with socioeconomic disadvantage, psychological distress, smoking, and excess body fat, which researchers found converge to trigger inflammation when elevated over time.
  • People with the highest inflammation levels faced a 43% greater risk of heart attack and stroke than those with the lowest; those with higher levels also showed structural changes, including thickened heart walls and smaller heart chambers.
  • Professor Bryan Williams, Chief Scientific and Medical Officer at the British Heart Foundation, said the research identifies inflammatory proteins that "appear to play a key role" in heart damage, offering potential for anti-inflammatory medicines.
  • While the study was observational, researchers emphasize that physical activity and healthier diets can help protect heart health. "But while tackling health inequalities remains an issue, there are things that we can do about inflammation," experts noted.
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Medical Xpress broke the news in Douglas, United Kingdom on Friday, September 18, 2026.
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