Characterization of single neurons reprogrammed by pancreatic cancer

Pancreatic cancer: Blocked nerves as a possible new treatment strategy

Pancreatic cancer is fueled by connections to the nervous system. This is reported by scientists from the German Cancer Research Center (DKFZ) and the Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM) in Nature.

Characterization of single neurons reprogrammed by pancreatic cancer

The peripheral nervous system (PNS) orchestrates organ function in health and disease. Most cancers including pancreatic ductal adenocarcinoma (PDAC) are infiltrated by PNS neurons, contributing to the complex tumor microenvironment (TME)1,2. However, neuronal cell bodies reside in various PNS ganglia, far from the tumor mass. Thus, cancer or healthy organ-innervating neurons elude current tissue sequencing datasets. To molecularly characterize …

Exploring Blocked Nerves as an Innovative Treatment Strategy for Pancreatic

A recent groundbreaking study published in Nature highlights the intricate relationship between pancreatic cancer and the nervous system, revealing how tumor cells manipulate neural connections to fuel their growth. Conducted by an interdisciplinary team at the German Cancer Research Center (DKFZ) and the Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM), this research has uncovered the extent to which pancreatic …

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For several years, scientists have been discovering interactions with the nervous system in almost all types of cancer studied, interactions that in many cases promote tumor growth and survival. This also applies to pancreatic cancer, which is interwoven with a dense network of nerves. However, only the nerve fibers project into the tumor, while the nuclei of the nerve cells lie far outside, in the ganglia, the control centers of the peripheral …

Cheap Blood Test Detects Pancreatic Cancer Before It Spreads

Maskot/Getty Researchers have developed a simple blood test to detect pancreatic cancer before it spreads to other sites in the body. The test could be used for routine screening to improve the disease’s low survival rate. “It’s a very pragmatic, really translatable solution” that builds on many advances in the field, says Simone Schürle-Finke, a biomedical engineer at Swiss Federal Institute of Technology (ETH) in Zurich, Switzerland. The resul…