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Cardinals vs. Saints Prediction, Odds and Preview for Week 1 NFL Game at Caesars Superdome

The Cardinals enter as 6.5-point favorites with a 73% win probability in simulations, while the Saints rely on rookie quarterback Spencer Rattler's first start for a home advantage.

Summary by Syracuse NY
The Cardinals visit the Saints in Week 1 of the 2025 NFL season. Dimers.com simulations project a 24-18 Arizona win, with New Orleans holding a 57% chance to cover the spread.

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Bias Distribution

  • 67% of the sources are Center
67% Center

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Sports Illustrated broke the news in New York, United States on Saturday, September 6, 2025.
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