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Zepbound beats Wegovy for weight loss in first head-to-head trial of blockbuster drugs

  • On May 11, 2025, a clinical trial in the U.S. Compared Eli Lilly's Zepbound and Novo Nordisk's Wegovy for weight loss.
  • The trial tested weekly injections over 72 weeks among 751 overweight or obese adults with related health issues but without diabetes.
  • Zepbound targets GLP-1 and GIP hormones and led to an average 20.2% weight loss, outperforming Wegovy's 13.7% which targets GLP-1 alone.
  • Participants on Zepbound lost 50.3 pounds on average versus 33.1 pounds with Wegovy, and nearly 32% lost at least 25% body weight compared to 16% on Wegovy.
  • The results suggest Zepbound offers superior weight loss effectiveness, although both drugs have similar side effects, influencing diverse obesity treatment options.
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WGN 9 broke the news in Chicago, United States on Sunday, May 11, 2025.
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