Zepbound beats Wegovy for weight loss in first head-to-head trial of blockbuster drugs
- On May 11, 2025, a clinical trial in the U.S. Compared Eli Lilly's Zepbound and Novo Nordisk's Wegovy for weight loss.
- The trial tested weekly injections over 72 weeks among 751 overweight or obese adults with related health issues but without diabetes.
- Zepbound targets GLP-1 and GIP hormones and led to an average 20.2% weight loss, outperforming Wegovy's 13.7% which targets GLP-1 alone.
- Participants on Zepbound lost 50.3 pounds on average versus 33.1 pounds with Wegovy, and nearly 32% lost at least 25% body weight compared to 16% on Wegovy.
- The results suggest Zepbound offers superior weight loss effectiveness, although both drugs have similar side effects, influencing diverse obesity treatment options.
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213 Articles
This GLP-1 Is the Most Effective for Weight Loss, Study Says
A new study says that people who use tirzepatide lose more weight than people who use semaglutide Getty Stock image of a woman weighing herself.Tirzepatide is more effective than semaglutide for weight loss, according to a new study on GLP-1 medications The study was funded by Eli Lilly, the pharmaceutical company that manufactures tirzepatide, so "take that with a grain of salt," one expert saidTirzepatide, which reduces appetite and improves h…
PODCAST: CFRA's House Calls for Sun. May 11th, 2025
Eli Lilly has plastered a 'fat tax' on the Canadian market for their weight loss drug. Dr. Yoni Freedhoff joins the program with his reaction. Then, Dr. Dworkin opens the phone lines and reads your texts.
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