Targeting brain’s waste removal system may help combat cognitive decline

The free-energy principle: a unified brain theory?

Karl Friston shows that different global brain theories all describe principles by which the brain optimizes value and surprise. He discusses how these brain theories fit into the free-energy framework, suggesting that this framework might provide a unified account of brain function. A free-energy principle has been proposed recently that accounts for action, perception and learning. This Review looks at some key brain theories in the biological

Targeting brain’s waste removal system may help combat cognitive decline

As aging bodies decline, the brain loses the ability to cleanse itself of waste, a scenario that scientists think could be contributing to neurodegenerative conditions such as Alzheimer's disease and Parkinson's disease, among others.

Boosting brain's waste removal system improves memory in old mice

Aging compromises the lymphatic vessels surrounding the brain, disabling waste drainage from the brain and impacting cognitive function. Researchers boosted lymphatic vessel integrity in old mice and found improvements in their memory compared with old mice without rejuvenated lymphatic vessels.

Loss of excitatory inputs and decreased tonic and evoked activity of locus coeruleus neurons in aged P301S mice

Tau pathology in the locus coeruleus (LC) is associated with several neurodegenerative conditions including Alzheimer's disease and frontotemporal dem…

Neuroscience in medicine seeks to develop methods of rahabiltiation for mental and neurodegenerative diseases.

Parkinson's Gut Bacteria Link Suggests an Unexpected, Simple Treatment

Researchers have suspected for some time that the link between our gut and brain plays a role in the development of Parkinson's disease.