BCG Immunotherapy Reprograms Bone Marrow to Boost Cancer Defense

BCG immunotherapy reprograms bone marrow to boost cancer defense

More than three decades ago, the U.S. Food and Drug Administration (FDA) approved Bacillus Calmette-Guérin (BCG) as the first immunotherapy against cancer. And it is still used today to treat early-stage bladder cancer.

Bladder cancer treatment reprograms bone marrow to boost immune system's cancer-fighting ability

More than three decades ago, the U.S. Food and Drug Administration (FDA) approved Bacillus Calmette-Guérin (BCG) as the first immunotherapy against cancer. And it is still used today to treat early-stage bladder cancer.

Old Vaccine, New Tricks: PIE-seq Reveals How BCG Reprograms Immunity

How can a tuberculosis vaccine also treat cancer—and potentially make other immunotherapies more effective? That’s the question researchers at Memorial Sloan Kettering Cancer Center (MSK) and Weill Cornell Medicine are helping answer with new insights into Bacillus Calmette-Guérin (BCG), a live attenuated strain of Mycobacterium bovis developed in 1921 as the first—and still only—vaccine against tuberculosis. Decades later, BCG was repurposed as…

Antidepressants May Boost Antitumor Immunity

Blocking serotonin transporters with antidepressants boosted CD8 T cell function and enhanced immunotherapy response in mouse and human tumor models.

William L. Fischer’s “How to Fight Cancer and Win” offers hope in the fight against cancer

Cancer involves uncontrolled growth of abnormal cells, forming malignant tumors that can spread and damage organs. Survival rates have improved (over 50 percent today vs.

BCG Immunotherapy Found to Reprogram Bone Marrow for Enhanced Cancer-Fighting Immune Response

Researchers have identified a mechanism by which Bacill […] The post BCG Immunotherapy Found to Reprogram Bone Marrow for Enhanced Cancer-Fighting Immune Response first appeared on GeneOnline News. The post BCG Immunotherapy Found to Reprogram Bone Marrow for Enhanced Cancer-Fighting Immune Response appeared first on GeneOnline News.