Assessing the impact of viscosity lowering excipient on liquid-liquid phase separation for high concentration monoclonal antibody solutions - Pharma Excipients

Assessing the impact of viscosity lowering excipient on liquid-liquid phase separation for high concentration monoclonal antibody solutions - Pharma Excipients

Abstract With continued interest in high concentration monoclonal antibody drug products to meet subcutaneous administration requirements, there is heightened attention on balancing protein-protein interactions, solution properties and overcoming instabilities such as increased in viscosity, particle formation, loss in potency, and aggregation of drug products. L-arginine hydrochloride is a commonly used viscosity reducing excipient used to infl…