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Artificial Sweetener Xylitol Associated with Higher Risk of Adverse Cardiovascular Events

Researchers found a dose-dependent link between higher xylitol blood levels and major cardiovascular events in 17,710 people, with the highest group facing 57% greater risk.

  • Higher blood levels of the artificial sweetener xylitol are linked to an increased risk of major adverse cardiovascular events, including heart attack and stroke, according to a study presented at the ESC Cardiology Congress.
  • In two large cohorts totaling over 17,700 British and Canadian participants, those with the highest xylitol levels had a 57% increased risk of cardiovascular events over six years in Canada and an 18% increase over 30 years in the UK.
  • The association between xylitol levels and cardiovascular events remained significant and dose-dependent after adjusting for factors such as age, gender, body mass index, hypertension, diabetes, and lipid levels.
  • The study was observational and does not prove causation; further research is needed to clarify xylitol's cardiovascular safety as it is widely used as a sugar substitute.
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Xilitol, a sweetener used as an alternative to sugar, is associated with a higher risk of myocardial infarction, stroke and death, according to a new study presented at the Congress of the European Cardiology Society (ESC) 2026. Researchers stress, however, that the results do not demonstrate that xylitol directly causes these cardiovascular problems.

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Medical Xpress broke the news in Douglas, United Kingdom on Wednesday, August 26, 2026.
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