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Cardinals QB Kyler Murray sits out of Wednesday's practice because of a foot injury

Kyler Murray’s foot injury leaves his Week 6 status uncertain as the Cardinals seek to end a three-game losing streak, facing a top-ranked Colts defense.

  • On Wednesday, Kyler Murray will miss practice with a foot injury and Jonathan Gannon listed him day-to-day, clouding his availability for Week 6 at the Indianapolis Colts on Oct. 12.
  • During Week 5, Kyler Murray suffered a foot injury late in the third quarter against the Tennessee Titans after a shotgun snap hit his face, causing a fumble and brief exit.
  • The Cardinals have lost three straight and sit 2-3, while Kyler Murray has completed 110 of 161 passes for 962 yards with six touchdowns and three interceptions.
  • If Murray can't play, Jacoby Brissett would start for Arizona, facing a Colts defense that allows the third-fewest points and forces the third-most interceptions.
  • Amid Murray's injury history, he hasn't missed a game since his 2023 torn ACL recovery, and the Cardinals face added strain after fining head coach Jonathan Gannon $100,000.
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Sportsnet broke the news in Canada on Wednesday, October 8, 2025.
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