US EditionNanotechnology Breakthrough Reverses Alzheimer’s Disease in Mice
Researchers used bioactive supramolecular nanoparticles to restore blood-brain barrier function, reducing amyloid-beta by up to 60% and reversing Alzheimer's symptoms in mice.
- The Institute for Bioengineering of Catalonia and West China Hospital of Sichuan University co-led a team that used bioactive nanoparticles called supramolecular drugs to reverse Alzheimer's pathology in mouse models.
- LRP1 normally acts as a molecular gatekeeper, recognizing amyloid-β, but when its binding fails, Aβ accumulates in the brain, impairing neurons and driving Alzheimer's disease.
- In experiments, genetically engineered mice producing high levels of beta-amyloid received just three doses and `Only 1h after the injection we observed a reduction of 50-60% in Aβ amount inside the brain`, with long-term tests showing full cognitive recovery.
- Researchers say the supramolecular drug nanoparticles mimic LRP1 ligands to bind Aβ, cross the BBB, and activate a feedback mechanism restoring vascular clearance.
- The study underscores the brain's vast vasculature—approximately one billion capillaries—and positions supramolecular drugs as a novel alternative to traditional nanomedicine for dementia therapy.
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Scientists Pioneer Alzheimer's Treatment Using Nanoparticles
Mouse brain after 12h of new Alzheimer’s treatment. Credit: Junyang Chen / CC BY 4.0 In a breakthrough study, scientists have developed a novel Alzheimer’s treatment using nanoparticles that not only slows disease progression but reverses brain damage in mice. The therapy, created by researchers at the Institute for Bioengineering of Catalonia (IBEC) and West China Hospital at Sichuan University, targets the brain’s vascular system rather than n…
Scientists achieve striking reversal of Alzheimer’s in mice using nanotechnology
Scientists achieve a striking reversal of Alzheimers in mice using nanotechnology. The therapy restores blood–brain barrier function, rapidly clears toxic amyloid-β proteins, and improves cognitive performance. Researchers say this breakthrough highlights the importance of vascular health and offers hope for future human treatments, potentially slowing disease progression and enhancing current therapies.
Nanotechnology breakthrough reverses Alzheimer’s disease in mice
A research team co-led by the Institute for Bioengineering of Catalonia (IBEC) and West China Hospital Sichuan University (WCHSU), working with partners in the UK, has demonstrated a nanotechnology strategy that reverses Alzheimer's disease in mice.
Scientists reverse Alzheimer's in mice using nanoparticles
A research team co-led by the Institute for Bioengineering of Catalonia (IBEC) and West China Hospital Sichuan University (WCHSU), working with partners in the UK, has demonstrated a nanotechnology strategy that reverses Alzheimer's disease in mice.
Scientists reverse Alzheimer's in mice using nanoparticles - Science Tech Updates
A research team co-led by the Institute for Bioengineering of Catalonia (IBEC) and West China Hospital Sichuan University (WCHSU), working with partners in the UK, has demonstrated a nanotechnology strategy that reverses Alzheimer’s disease in mice. Unlike traditional nanomedicine, which relies on nanoparticles as carriers for therapeutic molecules, this approach employs nanoparticles that are bioactive […] The post Scientists reverse Alzheimer’…
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