Advancing amorphous solid dispersions through empirical and hybrid modeling of drug–polymer solubility and miscibility: A case study using Ibuprofen - Pharma Excipients
Summary by Pharma Excipients
1 Articles
1 Articles
Advancing amorphous solid dispersions through empirical and hybrid modeling of drug–polymer solubility and miscibility: A case study using Ibuprofen - Pharma Excipients
Abstract This study investigates the solubility and miscibility of ibuprofen (IBU) with four pharmaceutical polymers, KOLVA64®, KOL17PF®, HPMCAS, and Eudragit® EPO, using a combination of empirical and hybrid modeling approaches, supported by differential scanning calorimetry (DSC) experiments. Traditional group contribution methods based on Hildebrand and Hansen solubility parameters (Fedors, Hoftyzer–van Krevelen, and Just–Breitkreutz) showed …
Coverage Details
Total News Sources1
Leaning Left0Leaning Right0Center0Last UpdatedBias DistributionNo sources with tracked biases.
Bias Distribution
- There is no tracked Bias information for the sources covering this story.
Factuality
To view factuality data please Upgrade to Premium