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Advancing amorphous solid dispersions through empirical and hybrid modeling of drug–polymer solubility and miscibility: A case study using Ibuprofen - Pharma Excipients

Abstract This study investigates the solubility and miscibility of ibuprofen (IBU) with four pharmaceutical polymers, KOLVA64®, KOL17PF®, HPMCAS, and Eudragit® EPO, using a combination of empirical and hybrid modeling approaches, supported by differential scanning calorimetry (DSC) experiments. Traditional group contribution methods based on Hildebrand and Hansen solubility parameters (Fedors, Hoftyzer–van Krevelen, and Just–Breitkreutz) showed …
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Pharma Excipients broke the news in on Friday, August 22, 2025.
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