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Acetaminophen use during pregnancy does not increase risk of autism, ADHD: Review

The comprehensive review analyzed 43 studies and found no statistically significant increase in autism, ADHD, or intellectual disability risk from acetaminophen use in pregnancy.

  • Published Friday, a major meta-analysis pooling about 60 studies found that acetaminophen taken as directed in pregnancy is not linked to autism, ADHD or intellectual disability.
  • Earlier studies showed mixed results, leaving pregnant people unsure about acetaminophen safety as study authors noted symptoms like fever, infection, pain and inflammation may confound links to fetal brain development.
  • Focusing on sibling-comparison designs, the review emphasized studies comparing siblings with and without prenatal acetaminophen exposure and included follow-up longer than five years.
  • Study authors and clinicians said pregnant women should feel reassured that acetaminophen remains the recommended first-line option for pain or fever in pregnancy when used as directed, and ACOG advises the lowest effective dose for the shortest time with care for persistent or high fever.
  • Voices outside the study cautioned or criticized, including an HHS official who said it "does not resolve an important public health question; it sidesteps it," while President Donald Trump and the FDA debated acetaminophen's safety and Kenvue defended Tylenol.
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Center

When U.S. President Donald Trump said last year that taking Tylenol during pregnancy may be related to an increased risk of autism, Gynecobstetra Nathaniel DeNicola's consultation received a wave of questions and confusion, but...

Lean Right

New research confirms that paracetamol is safe to use during pregnancy and there is no evidence linking it to an increased risk of autism, ADHD, or developmental problems in children, refuting earlier claims by Donald Trump.

Lean Left

A review of 4,000 studies on drug safety during pregnancy supports its use as a first option to treat pain and fever

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Science Daily broke the news in United States on Friday, January 16, 2026.
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