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A new virus variant and lagging vaccinations may mean the US is in for a severe flu season

The H3N2 subclade K variant has seven mutations that may reduce vaccine effectiveness, causing concern for a potentially severe U.S. flu season amid delayed surveillance data.

  • This past week, the United States entered flu season with subclade K, a variant of influenza A, threatening harsher months ahead as seen in Japan, the United Kingdom, and Canada, the Global Center for Health Security reports.
  • Earlier this year, a new H3N2 variant emerged after multiple mutations, appearing after strain selection, so vaccine makers in the Northern Hemisphere did not target subclade K, creating a mismatch.
  • According to the CDC's FluView for the week ending Nov. 8, flu activity is low nationally but rising, especially in children, with test positivity, hospitalizations and WastewaterSCAN data also increasing; early lab data show about 63 percent of influenza A samples are H3N2.
  • Experts emphasize that the vaccine still substantially reduces severe outcomes, and the Centers for Disease Control and Prevention recommends annual flu vaccination for everyone ages 6 months and older, stressing protection for people over 65 and young children.
  • Amid a reporting gap caused by a 44‑day government shutdown, Dr. Natalie Azar said `We're flying a little bit blind` on Nov. 13, while a BMJ study predicts a severe U.K. season and experts say subclade K is likely in the U.S.
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42 Articles

Center

People get sick with the coronavirus all year round, but it often becomes an epidemic in the fall. That's why vaccinations are also focused on that time.

·Finland
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Left

A new flu variant has taken hold in Sweden. The so-called K mutation appears to both spread faster and cause more severe symptoms. – I would say that it

·Stockholm, Sweden
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A new virus variant and lagging vaccinations may mean the US is in for a severe flu season

The United States may be heading into its second severe flu season in a row, driven by a mutated strain called subclade K that’s behind early surges in the United Kingdom, Canada and Japan.

·Atlanta, United States
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EverydayHealth.com broke the news in on Monday, November 17, 2025.
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