Engineered Extracellular Vesicles Enable Antigen-Specific Regulatory T Cell Induction

Engineered extracellular vesicles enable antigen-specific regulatory T cell induction

A research team at the Nano Life Science Institute (WPI-NanoLSI) and the Faculty of Medicine at Kanazawa University has developed a new class of engineered extracellular vesicles (EVs) capable of inducing antigen-specific regulatory T cells (Tregs), the immune cells that play a central role in suppressing excessive immune responses.

A new strategy for immune tolerance: Engineered extracellular vesicles show promise

A research team at the Nano Life Science Institute (WPI-NanoLSI) and the Faculty of Medicine at Kanazawa University has developed a new class of engineered extracellular vesicles (EVs) capable of inducing antigen-specific regulatory T cells (Tregs), the immune cells that play a central role in suppressing excessive immune responses. The findings, now published in Drug Delivery, may pave the way for next-generation therapies for autoimmune and al…

Extracellular Vesicle-Based Platform Induces Antigen-Specific Tregs

Immune therapies that have used regulatory T cells (Tregs) have long been limited by difficulties in suppressing the harmful immune response in autoimmune disorders without compromising the immune system as a whole. While Tregs are the natural mechanism for maintaining immune tolerance, inducing antigen-specific Tregs safely and efficiently in patients has been difficult. Existing strategies often depend on broad immunosuppression or complex cel…