US EditionA Modified Herpes Virus Attacks Skin Cancer: Hope in Sight?
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About 15 years ago, in 2009, the team of the researcher of the National Center for Oncological Research (CNIO) Marisol Soengas discovered a new way to kill tumor cells: to make them believe that they have been infected by a virus. They developed a compound, called BO-110, with a very novel form of action because it induced the self-digestion of melanoma cells, the most lethal form of skin cancer. The result was so striking that Cancer Cell magaz…
A decade after the first steps of virotherapy, the medical world goes further. Scientists have succeeded in transforming the herpes virus into a formidable weapon against cancer. A phase 1/2 clinical trial has just proved this: the RP1, a genetically modified herpes simplex virus, has succeeded in reducing advanced melanoma tumours, even deeply rooted in the body. A discovery that could well change the deal for thousands of patients.
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