US EditionFOXP4 Gene Variants Reveal New Genetic Link to Long COVID Risk
- Researchers published a study on May 23, 2025, identifying FOXP4 gene variants linked to long COVID risk from data across 19 countries.
- The analysis included nearly sixteen thousand individuals with long COVID and close to 1.9 million control participants, supporting evidence that ongoing symptoms persist in approximately 10 to 70 percent of those who have recovered from the initial infection.
- Meta-Analysis showed FOXP4 variants independently increase long COVID risk, emphasizing lung function's role and confirming the lead variant rs9367106-C with an odds ratio of 1.63.
- Hugo Zeberg explained that reduced lung capacity is an important factor in the onset of long COVID, but emphasized that the gene variant is only one element among many contributing factors.
- The findings highlight genetic and environmental interplay in long COVID, suggesting vaccination may protect and that risk allele frequencies vary by ancestry, informing future research.
12 Articles
12 Articles
The risk of Long Covid symptoms: a systematic review and meta-analysis of controlled studies
The global evidence on the risk of symptoms of Long Covid in general populations infected with SARS-CoV-2 compared to uninfected comparator/control populations remains unknown. We conducted a systematic literature search using multiple electronic databases from January 1, 2022, to August 1, 2024. Included studies had ≥100 people with confirmed or self-reported COVID-19 at ≥28 days following infection onset, and an uninfected comparator/control g…
FOXP4 gene variants reveal new genetic link to long COVID risk
Researchers have identified genetic variants in the FOXP4 gene that significantly increase the risk of developing long COVID, independently of COVID-19 severity. The study also reveals that ancestry, smoking, and other factors contribute to the complex genetics of long COVID.
Gene variant linked to higher risk of long COVID symptoms
An international team of researchers has found a genetic link to long-term symptoms after COVID-19. The identified gene variant is located close to the FOXP4 gene, which is known to affect lung function. The study, published in Nature Genetics, was led by researchers at Karolinska Institutet in Sweden and the Institute for Molecular Medicine in Finland.
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