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A design of experiment approach to identify the most stable composition of a ternary co-amorphous system - Pharma Excipients

Summary by Pharma Excipients
Abstract Ternary co-amorphous systems, comprising a drug, a low molecular weight co-former, and a polymer, are a promising approach to address the solubility and stability challenges of poorly water-soluble drugs. However, it is unclear how the addition of a third component influences the stability of the binary system and how to identify the optimal composition of a ternary system. In previous studies we calculated weight percentages of the com…
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A design of experiment approach to identify the most stable composition of a ternary co-amorphous system - Pharma Excipients

Abstract Ternary co-amorphous systems, comprising a drug, a low molecular weight co-former, and a polymer, are a promising approach to address the solubility and stability challenges of poorly water-soluble drugs. However, it is unclear how the addition of a third component influences the stability of the binary system and how to identify the optimal composition of a ternary system. In previous studies we calculated weight percentages of the com…

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Pharma Excipients broke the news in on Wednesday, April 2, 2025.
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