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The Nobel Prize in medicine goes to 3 scientists for work on peripheral immune tolerance
- On October 6, 2025, the Nobel Assembly at Karolinska Institutet awarded the 2025 Nobel Prize in Physiology or Medicine to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi for discoveries concerning peripheral immune tolerance.
- Brunkow and Ramsdell traced a Foxp3 gene mutation in mice linked to autoimmune vulnerability, while Sakaguchi showed Foxp3 governs regulatory T cells that prevent immune attacks on the body.
- The Nobel Assembly noted `The laureates' discoveries launched the field of peripheral tolerance, spurring the development of medical treatments for cancer and autoimmune diseases`, and the prize sum of 11 million Swedish kronor will be shared equally.
- Today the Nobel season began with the first award announced, and Thomas Perlmann said he reached Sakaguchi by phone, noting `He sounded incredibly grateful, expressed that it was a fantastic honour and he was quite taken by the news.`
- The Nobel Prizes have been awarded since 1901 and their ceremonies culminate on December 10, according to the Nobel Assembly.
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157 Articles
This year's Nobel Prize in Medicine is awarded to researchers who have achieved a breakthrough that gives hope to millions of people. Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi demonstrated with their pioneering discoveries on so-called peripheral immune tolerance how the immune system is prevented from attacking its own body – a milestone for the treatment of autoimmune diseases, cancer and transplantation complications. Shimon Sakaguc…
·Vienna, Austria
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Their discovery explains how the body prevents autoimmune diseases. The findings could help to find treatments for neurodermatitis, multiple sclerosis or type 1 diabetes.
·Zürich, Switzerland
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