Testing BRCA1 variants reveals differences in breast cancer risk

Testing BRCA1 variants reveals differences in breast cancer risk

Researchers at the Francis Crick Institute have tested thousands of possible BRCA1 mutations in mammary gland cells to shed light on which genetic variants confer a high risk of developing breast cancer. Research like this holds potential to improve how genetic results are interpreted in the future.

Testing BRCA1 Variants Across Cell Types Clarifies Breast Cancer Risk

Researchers using saturation genome editing across cell types found that mammary cells can buffer some BRCA1 mutations, helping distinguish high-risk variants from intermediate cancer risks.