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Your body feels cold in two different ways

The study reveals that skin and internal organs use distinct ion channels TRPM8 and TRPA1 for cold sensing, advancing understanding of thermal regulation and cold sensitivity disorders.

Summary by Science Daily
Researchers have uncovered that the body uses different molecular systems to sense cold in the skin versus internal organs. This explains why surface chills feel very different from cold experienced deep inside the body.

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The study shows that the skin and internal organs use different molecular mechanisms to detect cold.

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A team led by researcher Félix Viana, co-director of the Laboratory of Sensory Transduction and Nociception of the Institute of Neurosciences (IN), center of the Higher Council of Scientific Research (CSIC) and the Miguel Hernández University (UMH) of Elche, has shown that the body uses different molecular mechanisms to detect the cold in the skin and internal organs. The results of the research, carried out in animal models, represent an advanc…

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Medical Xpress broke the news in on Thursday, December 18, 2025.
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