Yale Researchers Triple Precision and Efficiency in Genome Editing

Next-generation materials for nucleic acid delivery

Efficient and targeted delivery of nucleic acids is critical for realizing the full therapeutic potential of gene editing, vaccines and RNA-based drugs, and emerging delivery platforms offer innovative solutions through their diverse architectures, tunable properties and distinct biological interactions. In this Viewpoint, researchers working across different delivery platforms — including lipid nanoparticles, synthetic polymers, peptide amphiph…

Yale researchers triple precision and efficiency in genome editing

The promise of genome editing to help understand human diseases and create new therapies is vast, but technological limitations have limited advancement of the field.

Yale Genome Engineers Enhance Precision and Scope of Human Gene Editing

The rapid evolution of genome editing technologies has ushered in an era where the potential to understand and treat human diseases appears nearly limitless. Recent advancements, particularly in the realm of multiplexed editing, promise to push the boundaries of what is possible within genetic research and therapy. Traditional gene editing methods, including the widely recognized CRISPR-Cas9, have allowed for modifications at single genomic loca…