US EditionErythritol Alters Brain Vessel Function and May Raise Stroke Risk
UNITED STATES AND EUROPE, JUL 21 – The study links erythritol to oxidative stress and impaired blood clot breakdown in brain vessels, with those having high blood levels facing double the risk of stroke, researchers said.
- In laboratory experiments, researchers found adverse effects on human brain microvascular endothelial cells, observing dysfunction after three-hour exposure to drink-level erythritol, which may raise ischemic stroke risk.
- Despite its safety status, erythritol has been used since FDA approval in 2001, and it avoided WHO's artificial sweetener guidelines.
- In cellular tests, erythritol triggered oxidative stress and altered vessel-regulating molecules, and it blunted clot-dissolving activity when thrombin was applied.
- A large cohort study found doubled cardiac event risk among top erythritol consumers, and Auburn Berry said this blunted clot breakdown and constricted vessels raise stroke danger.
- Given the uncertainties, they urge consumers to reconsider erythritol use, and health experts call for more human studies to assess cardiovascular risk.
13 Articles
13 Articles
Sugar substitutes are intended to make sweet life easier. However, the substances also have unwanted effects. Researchers in the laboratory take a closer look at a sweetener that has hitherto been considered safe - and discover worrying chain reactions.
Popular Sugar Substitute Linked to Higher Risk of Stroke
A widely used sugar substitute found in some sugar-free and low-calorie foods may not be as benign as previously thought, according to a new study. Small amounts of erythritol, which was approved by the Food and Drug Administration (FDA) in 2001, may damage brain blood vessel cells and could lead to a higher chance of stroke, researchers from the University of Colorado said in a news release. Erythritol is considered a sugar alcohol, produced mo…
The Conversation
Western Morning NewsHow a popular sweetener could be damaging your brain’s defences – new study
Found in everything from protein bars to energy drinks, erythritol has long been considered a safe alternative to sugar. But new research suggests this widely used sweetener may be quietly undermining one of the body’s most crucial protective barriers – with potentially serious consequences for heart health and stroke risk. A new study from the University of Colorado suggests erythritol may damage cells in the blood-brain barrier, the brain’s se…
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