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New WHO Guidelines Recommend Injectable Lenacapavir for HIV Prevention

GLOBAL, JUL 14 – WHO urges rapid adoption of lenacapavir injection to address stagnant HIV prevention amid 1.3 million new infections and 40.8 million living with HIV globally in 2024.

  • On July 14, 2025, during the IAS 2025 conference in Kigali, WHO announced new guidelines recommending injectable lenacapavir twice yearly for HIV prevention.
  • This recommendation follows the recent FDA approval of LEN and emerges amid major funding cuts disrupting global HIV treatment and prevention programs.
  • LEN offers a long-acting alternative to daily oral pills, shown in trials to prevent nearly all HIV infections, benefiting those with adherence or access challenges.
  • WHO Director-General Tedros Ghebreyesus called LEN "the next best thing" in HIV prevention as 1.3 million new HIV infections occurred globally in 2024.
  • WHO urged governments and partners to urgently roll out LEN within national programs, emphasizing bold, equitable implementation despite ongoing financial and social barriers.
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The World Health Organization (WHO) recommended that countries include lenacapavir for the prevention of human immunodeficiency virus (HIV). The drug was recently approved and is considered a tool to combat HIV infections, especially for groups at higher risk and in high-burden areas of the disease. The global recommendation, issued Monday at the International AIDS Conference in Kigali, Rwanda, comes about a month after the US Food and Drug Admi…

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UN News broke the news in New York, United States on Monday, July 14, 2025.
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