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When Prognosis Becomes Probabilistic
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When Prognosis Becomes Probabilistic
Cancer immunotherapy and mRNA-based oncology platforms have not abolished mortality, but they have unsettled its predictability. Immune checkpoint inhibitors targeting PD-1 and CTLA-4 pathways—first validated in pivotal trials published in outlets such as The New England Journal of Medicine (https://www.nejm.org/doi/full/10.1056/NEJMoa1200690)—have demonstrated durable responses in subsets of patients once considered refractory. Meanwhile, mRNA …
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