Genetic Mutation Behind Orange Cat Fur Identified in Breakthrough Studies
- Researchers have discovered a DNA deletion responsible for the orange coat color in domestic cats, as detailed in a pair of studies released in Current Biology in mid-May.
- Researchers investigated this because the orange fur trait resides on the X chromosome and mostly occurs in male cats.
- Analyzing DNA from about 30 cats, teams found a deletion near Arhgap36 that increases its protein in pigment cells, reducing darker pigments.
- All 258 orange cats in a global database had this deletion while non-orange cats lacked it, confirming its role in ginger fur.
- The mutation likely originated over 900 years ago in one ancestral cat and is unique to domestic felines' ginger coloring.
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Orange cat mystery finally solved after discovery of genetic 'meow-tation'
Researchers have discovered how orange cats got their coats — and why so many of them are male. The coat color comes from a genetic mutation on the X chromosome of orange, calico and tortoiseshell cats.
·United States
Read Full ArticleThe DNA secret behind orange cats : Short Wave
Approximately 80% of orange cats are males, including the four orange cats owned by the Short Wave team. Scientists have long suspected that orange color was a sex-linked trait — hiding somewhere on the X chromosome. Now, scientists at Stanford University and Kyushu University in Japan have characterized the mutation responsible for orange cat coloration. Both groups published their results in the journal Cell Biology this week. Have a question …
·Washington, United States
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