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Chemists Recreate How RNA Might Have Reproduced for First Time

  • Scientists at University College London developed a network of RNA strands capable of limited self-replication under laboratory conditions.
  • This work builds on the RNA World hypothesis, which suggests life began with self-replicating RNA molecules roughly 4 billion years ago, though evidence of the first replicator remains absent.
  • The team used RNA triplets that form stable interactions to stop the strands from rejoining, enabling replication of up to 30 letters of a 180-letter RNA enzyme; this process likely requires freshwater conditions, possibly found in geothermal land environments.
  • Lead author James Attwater stated, "RNA was the molecule that ran biology" and described three-letter triplets as the "sweet spot" for replication, noting intriguing properties in this simple molecular system.
  • Although full RNA self-replication has not yet been achieved, improving enzyme efficiency could enable complete replication, advancing understanding of how inert molecules may have sparked life on Earth.
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We’re getting close to recreating the first step in evolution of life

Life is thought to have begun when RNA began replicating itself, and researchers have got close to achieving this in the lab

·Baltimore, United States
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NewScientist broke the news in Baltimore, United States on Wednesday, May 28, 2025.
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