Chemists Recreate How RNA Might Have Reproduced for First Time
- Scientists at University College London developed a network of RNA strands capable of limited self-replication under laboratory conditions.
- This work builds on the RNA World hypothesis, which suggests life began with self-replicating RNA molecules roughly 4 billion years ago, though evidence of the first replicator remains absent.
- The team used RNA triplets that form stable interactions to stop the strands from rejoining, enabling replication of up to 30 letters of a 180-letter RNA enzyme; this process likely requires freshwater conditions, possibly found in geothermal land environments.
- Lead author James Attwater stated, "RNA was the molecule that ran biology" and described three-letter triplets as the "sweet spot" for replication, noting intriguing properties in this simple molecular system.
- Although full RNA self-replication has not yet been achieved, improving enzyme efficiency could enable complete replication, advancing understanding of how inert molecules may have sparked life on Earth.
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Template-directed synthesis of a genetic polymer in a model protocell
The phospholipids that form the membranes of modern cells present a formidable barrier to polar and charged molecules, necessitating complex channels and pumps to permit the exchange of molecules with the external environment. This presents a problem when trying to imagine what a primitive cell would have looked like earlier in the evolution of life. With no transport machinery, how could simple cells take in complex nutrients? A possible answer…
·United Kingdom
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We’re getting close to recreating the first step in evolution of life
Life is thought to have begun when RNA began replicating itself, and researchers have got close to achieving this in the lab
·Baltimore, United States
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