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The Risk of Depression, Anxiety, and Suicidal Behavior in Patients with Obesity on Glucagon Like Peptide-1 Receptor Agonist Therapy

  • Patients with obesity using GLP-1 receptor agonists like semaglutide and Mounjaro show reduced depression, anxiety, and suicidal behavior risks.
  • Scientists believe these medications enhance mental health by lowering bodily inflammation and improving insulin functioning, factors associated with depression and cognitive deterioration.
  • Multiple trials involving patients with and without mental illness demonstrated that GLP-1 therapies improve mood, emotional wellbeing, and reduce psychological distress.
  • Dr. Breit emphasized that individuals with serious mental health conditions are at a significantly higher risk—approximately triple—of experiencing obesity, and highlighted the role of these medications in effectively managing this challenge.
  • Experts note these weight-loss drugs have potential wide-ranging benefits and encourage updating clinical guidelines as further research unfolds.
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Sydney Morning Herald broke the news in Sydney, Australia on Saturday, May 17, 2025.
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