Mechanisms of Disease: β-Adrenergic Receptors—Alterations in Signal Transduction and Pharmacogenomics in Heart Failure

Mechanisms of Disease: β-adrenergic receptors—alterations in signal transduction and pharmacogenomics in heart failure

Alterations in β-adrenergic-receptor signal transduction play a major part in the development of heart failure. Although pharmacologic and device-based therapy can lessen morbidity and mortality, better understanding of these mechanisms should improve outcomes. Much of the current understanding of β-adrenergic signaling pathways and polymorphisms is summarized in this review. β-adrenergic signaling is an important regulator of myocardial functio…

Waist-to-height ratio predicts heart failure incidence, study indicates

Waist-to-height ratio predicts heart failure incidence, according to research presented at Heart Failure 2025.