Plasma Metabolomic Profiles Associated with Mortality and Longevity in a Prospective Analysis of 13,512 Individuals

Plasma metabolomic profiles associated with mortality and longevity in a prospective analysis of 13,512 individuals

Experimental studies reported biochemical actions underpinning aging processes and mortality, but the relevant metabolic alterations in humans are not well understood. Here we examine the associations of 243 plasma metabolites with mortality and longevity (attaining age 85 years) in 11,634 US (median follow-up of 22.6 years, with 4288 deaths) and 1878 Spanish participants (median follow-up of 14.5 years, with 525 deaths). We find that, higher le…

Use of metformin associated with exceptional longevity among older women

There is increasing interest in finding drugs, known as gerotherapeutics, that can slow aging and help people live longer. Metformin, a common diabetes drug, is being studied because it affects several aging-related processes.