US EditionUnlocking the potential of microfluidic assisted formulation of exenatide-loaded solid lipid nanoparticles - Pharma Excipients
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Unlocking the potential of microfluidic assisted formulation of exenatide-loaded solid lipid nanoparticles - Pharma Excipients
Abstract Exenatide, a first-in-class GLP-1 receptor agonist, is used to control glycaemic levels in type 2 diabetes. There are two approved injectable formulations: one solution for immediate action and one dispersion for prolonged action. Oral exenatide has low bioavailability due to poor gastrointestinal stability and absorption. To address these obstacles, we designed Solid Lipid Nanoparticles (SLN) including DOTAP in the formulation to yield…
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