Ultrapotent SARS coronavirus-neutralizing single-domain antibodies that clamp the spike at its base

Ultrapotent SARS coronavirus-neutralizing single-domain antibodies that clamp the spike at its base

Therapeutic monoclonal antibodies can prevent severe disease in SARS-CoV-2 exposed individuals. However, currently circulating virus variants have evolved to gain significant resistance to nearly all neutralizing human immune system-derived therapeutic monoclonal antibodies that had previously been emergency-authorized for use in the clinic. Here, we describe the discovery of a panel of single-domain antibodies (VHHs) directed against the spike …