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Toxin produced by E. coli ‘could be driving bowel cancer rates in young people’

  • A new study found that early exposure to a gut toxin called colibactin may increase bowel cancer rates in young people.
  • Researchers at the University of California San Diego reported that colibactin-related mutations are over three times more common in patients under 40 than those over 70.
  • Around 50% of early-onset colorectal cancers in individuals under 40 carry the signature of colibactin exposure, according to senior study author Ludmil Alexandrov.
  • Colibactin may leave specific DNA mutation patterns, and exposure to it could lead to earlier colorectal cancer development.
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Jenny broke the news in on Wednesday, April 23, 2025.
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