'Revolutionary': Scientists Create Mice with Two Fathers
- Scientists in Japan led by Katsuhiko Hayashi created seven mice born using eggs derived from male cells, reported on 2025-06-25 in Nature.
- The breakthrough stemmed from efforts to achieve androgenesis, a rare process using two paternal genetic materials in egg cells, overcoming prior low survival rates.
- Researchers implanted two modified sperm cells into eggs without nuclei, successfully eradicating trisomy 16 and producing fertile adult mice.
- The study yielded a 1.1 percent survival rate from 630 implanted embryos, with seven survivors now fertile and having produced offspring, described as a "milestone in reproductive biology."
- While the technique opens new possibilities for bipaternal reproduction and fertility treatments, scientists stress it requires further work and ethical discussions before human applications.
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How mice with two dads bring us closer to two men having a child of their own
Mice with two fathers have, for the first time, gone on to have babies of their own, showing that mice created with two sperm cells can be healthy and fertile – and paving the way to a future in which two men may be able to have a genetically related child.There are huge barriers to overcome before this could become a reality for humans, but the mouse breakthrough, led by Yanchang Wei at Shanghai Jiao Tong University in China and published in PN…
·Washington, United States
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