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'Revolutionary': Scientists Create Mice with Two Fathers

  • Scientists in Japan led by Katsuhiko Hayashi created seven mice born using eggs derived from male cells, reported on 2025-06-25 in Nature.
  • The breakthrough stemmed from efforts to achieve androgenesis, a rare process using two paternal genetic materials in egg cells, overcoming prior low survival rates.
  • Researchers implanted two modified sperm cells into eggs without nuclei, successfully eradicating trisomy 16 and producing fertile adult mice.
  • The study yielded a 1.1 percent survival rate from 630 implanted embryos, with seven survivors now fertile and having produced offspring, described as a "milestone in reproductive biology."
  • While the technique opens new possibilities for bipaternal reproduction and fertility treatments, scientists stress it requires further work and ethical discussions before human applications.
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futurezone.at broke the news in on Tuesday, June 24, 2025.
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